diff --git a/drivers/vfio/pci/vfio_pci.c b/drivers/vfio/pci/vfio_pci.c
index 706de3e..e1c156e 100644
--- a/drivers/vfio/pci/vfio_pci.c
+++ b/drivers/vfio/pci/vfio_pci.c
@@ -407,6 +407,14 @@ static int vfio_pci_enable(struct vfio_pci_device *vdev)
 		}
 	}
 
+	if (IS_ENABLED(CONFIG_VFIO_PCI_ZDEV)) {
+		ret = vfio_pci_zdev_io_init(vdev);
+		if (ret && ret != -ENODEV) {
+			pci_warn(pdev, "Failed to setup zPCI I/O region\n");
+			return ret;
+		}
+	}
+
 	vfio_pci_probe_mmaps(vdev);
 
 	return 0;
diff --git a/drivers/vfio/pci/vfio_pci_private.h b/drivers/vfio/pci/vfio_pci_private.h
index 5c90e56..bc49980 100644
--- a/drivers/vfio/pci/vfio_pci_private.h
+++ b/drivers/vfio/pci/vfio_pci_private.h
@@ -217,12 +217,18 @@ static inline int vfio_pci_ibm_npu2_init(struct vfio_pci_device *vdev)
 #ifdef CONFIG_VFIO_PCI_ZDEV
 extern int vfio_pci_info_zdev_add_caps(struct vfio_pci_device *vdev,
 				       struct vfio_info_cap *caps);
+extern int vfio_pci_zdev_io_init(struct vfio_pci_device *vdev);
 #else
 static inline int vfio_pci_info_zdev_add_caps(struct vfio_pci_device *vdev,
 					      struct vfio_info_cap *caps)
 {
 	return -ENODEV;
 }
+
+static inline int vfio_pci_zdev_io_init(struct vfio_pci_device *vdev)
+{
+	return -ENODEV;
+}
 #endif
 
 #endif /* VFIO_PCI_PRIVATE_H */
diff --git a/drivers/vfio/pci/vfio_pci_zdev.c b/drivers/vfio/pci/vfio_pci_zdev.c
index 57e19ff..a962043 100644
--- a/drivers/vfio/pci/vfio_pci_zdev.c
+++ b/drivers/vfio/pci/vfio_pci_zdev.c
@@ -18,6 +18,7 @@
 #include <linux/vfio_zdev.h>
 #include <asm/pci_clp.h>
 #include <asm/pci_io.h>
+#include <asm/pci_insn.h>
 
 #include "vfio_pci_private.h"
 
@@ -143,3 +144,160 @@ int vfio_pci_info_zdev_add_caps(struct vfio_pci_device *vdev,
 
 	return ret;
 }
+
+static size_t vfio_pci_zdev_io_rw(struct vfio_pci_device *vdev,
+				  char __user *buf, size_t count,
+				  loff_t *ppos, bool iswrite)
+{
+	unsigned int i = VFIO_PCI_OFFSET_TO_INDEX(*ppos) - VFIO_PCI_NUM_REGIONS;
+	struct vfio_region_zpci_io *region = vdev->region[i].data;
+	struct zpci_dev *zdev = to_zpci(vdev->pdev);
+	loff_t pos = *ppos & VFIO_PCI_OFFSET_MASK;
+	void *base = region;
+	struct page *gpage;
+	void *gaddr;
+	u64 *data;
+	int ret;
+	u64 req;
+
+	if ((!vdev->pdev->bus) || (!zdev))
+		return -ENODEV;
+
+	if (pos >= vdev->region[i].size)
+		return -EINVAL;
+
+	count = min(count, (size_t)(vdev->region[i].size - pos));
+
+	if (!iswrite) {
+		/* Only allow reads to the _hdr area */
+		if (pos + count > offsetof(struct vfio_region_zpci_io, req))
+			return -EFAULT;
+		if (copy_to_user(buf, base + pos, count))
+			return -EFAULT;
+		return count;
+	}
+
+	/* Only allow writes to the _req area */
+	if (pos < offsetof(struct vfio_region_zpci_io, req))
+		return -EFAULT;
+	if (copy_from_user(base + pos, buf, count))
+		return -EFAULT;
+
+	/*
+	 * Read operations are limited to 8B
+	 */
+	if ((region->req.flags & VFIO_ZPCI_IO_FLAG_READ) &&
+		(region->req.len > 8)) {
+		return -EIO;
+	}
+
+	/*
+	 * Block write operations are limited to hardware-reported max
+	 */
+	if ((region->req.flags & VFIO_ZPCI_IO_FLAG_BLOCKW) &&
+		(region->req.len > zdev->maxstbl)) {
+		return -EIO;
+	}
+
+	/*
+	 * While some devices may allow relaxed alignment for the PCISTB
+	 * instruction, the VFIO region requires the input buffer to be on a
+	 * DWORD boundary for all operations for simplicity.
+	 */
+	if (!IS_ALIGNED(region->req.gaddr, sizeof(uint64_t)))
+		return -EIO;
+
+	/*
+	 * For now, the largest allowed block I/O is advertised as PAGE_SIZE,
+	 * and cannot exceed a page boundary - so a single page is enough.  The
+	 * guest should have validated this but let's double-check that the
+	 * request will not cross a page boundary.
+	 */
+	if (((region->req.gaddr & ~PAGE_MASK)
+			+ region->req.len - 1) & PAGE_MASK) {
+		return -EIO;
+	}
+
+	mutex_lock(&zdev->lock);
+
+	ret = get_user_pages_fast(region->req.gaddr & PAGE_MASK, 1, 0, &gpage);
+	if (ret <= 0) {
+		count = -EIO;
+		goto out;
+	}
+	gaddr = page_address(gpage);
+	gaddr += (region->req.gaddr & ~PAGE_MASK);
+	data = (u64 *)gaddr;
+
+	req = ZPCI_CREATE_REQ(zdev->fh, region->req.pcias, region->req.len);
+
+	/* Perform the requested I/O operation */
+	if (region->req.flags & VFIO_ZPCI_IO_FLAG_READ) {
+		/* PCILG */
+		ret = __zpci_load(data, req,
+				region->req.offset);
+	} else if (region->req.flags & VFIO_ZPCI_IO_FLAG_BLOCKW) {
+		/* PCISTB */
+		ret = __zpci_store_block(data, req,
+					region->req.offset);
+	} else {
+		/* Undefined Operation or none provided */
+		count = -EIO;
+	}
+	if (ret < 0)
+		count = -EIO;
+
+	put_page(gpage);
+
+out:
+	mutex_unlock(&zdev->lock);
+	return count;
+}
+
+static void vfio_pci_zdev_io_release(struct vfio_pci_device *vdev,
+				     struct vfio_pci_region *region)
+{
+	kfree(region->data);
+}
+
+static const struct vfio_pci_regops vfio_pci_zdev_io_regops = {
+	.rw		= vfio_pci_zdev_io_rw,
+	.release	= vfio_pci_zdev_io_release,
+};
+
+int vfio_pci_zdev_io_init(struct vfio_pci_device *vdev)
+{
+	struct vfio_region_zpci_io *region;
+	struct zpci_dev *zdev;
+	int ret;
+
+	if (!vdev->pdev->bus)
+		return -ENODEV;
+
+	zdev = to_zpci(vdev->pdev);
+	if (!zdev)
+		return -ENODEV;
+
+	region = kmalloc(sizeof(struct vfio_region_zpci_io), GFP_KERNEL);
+
+	ret = vfio_pci_register_dev_region(vdev,
+		PCI_VENDOR_ID_IBM | VFIO_REGION_TYPE_PCI_VENDOR_TYPE,
+		VFIO_REGION_SUBTYPE_IBM_ZPCI_IO,
+		&vfio_pci_zdev_io_regops,
+		sizeof(struct vfio_region_zpci_io),
+		VFIO_REGION_INFO_FLAG_READ | VFIO_REGION_INFO_FLAG_WRITE,
+		region);
+
+	if (ret) {
+		kfree(region);
+		return ret;
+	}
+
+	/* Setup the initial header information */
+	region->hdr.flags = 0;
+	region->hdr.max = zdev->maxstbl;
+	region->hdr.reserved = 0;
+	region->hdr.reserved2 = 0;
+
+	return ret;
+}
diff --git a/include/uapi/linux/vfio.h b/include/uapi/linux/vfio.h
index d181277..5547f9b 100644
--- a/include/uapi/linux/vfio.h
+++ b/include/uapi/linux/vfio.h
@@ -338,6 +338,10 @@ struct vfio_region_info_cap_type {
  * to do TLB invalidation on a GPU.
  */
 #define VFIO_REGION_SUBTYPE_IBM_NVLINK2_ATSD	(1)
+/*
+ * IBM zPCI I/O region
+ */
+#define VFIO_REGION_SUBTYPE_IBM_ZPCI_IO		(2)
 
 /* sub-types for VFIO_REGION_TYPE_GFX */
 #define VFIO_REGION_SUBTYPE_GFX_EDID            (1)
diff --git a/include/uapi/linux/vfio_zdev.h b/include/uapi/linux/vfio_zdev.h
index b0b6596..830acca4 100644
--- a/include/uapi/linux/vfio_zdev.h
+++ b/include/uapi/linux/vfio_zdev.h
@@ -76,4 +76,37 @@ struct vfio_device_info_cap_zpci_pfip {
 	__u8 pfip[];
 };
 
+/**
+ * VFIO_REGION_SUBTYPE_IBM_ZPCI_IO - VFIO zPCI PCI Direct I/O Region
+ *
+ * This region is used to transfer I/O operations from the guest directly
+ * to the host zPCI I/O layer.  The same instruction requested by the guest
+ * (e.g. PCISTB) will always be used, even if the MIO variant is available.
+ *
+ * The _hdr area is user-readable and is used to provide setup information.
+ * The _req area is user-writable and is used to provide the I/O operation.
+ */
+struct vfio_zpci_io_hdr {
+	__u64 flags;
+	__u16 max;		/* Max block operation size allowed */
+	__u16 reserved;
+	__u32 reserved2;
+};
+
+struct vfio_zpci_io_req {
+	__u64 flags;
+#define VFIO_ZPCI_IO_FLAG_READ (1 << 0) /* Read Operation Specified */
+#define VFIO_ZPCI_IO_FLAG_BLOCKW (1 << 1) /* Block Write Operation Specified */
+	__u64 gaddr;		/* Address of guest data */
+	__u64 offset;		/* Offset into target PCI Address Space */
+	__u32 reserved;
+	__u16 len;		/* Length of guest operation */
+	__u8 pcias;		/* Target PCI Address Space */
+	__u8 reserved2;
+};
+
+struct vfio_region_zpci_io {
+	struct vfio_zpci_io_hdr hdr;
+	struct vfio_zpci_io_req req;
+};
 #endif
