diff --git a/target/mips/translate.h b/target/mips/translate.h
index 47129de81d9..cbaef53b958 100644
--- a/target/mips/translate.h
+++ b/target/mips/translate.h
@@ -161,6 +161,7 @@ extern TCGv bcond;
 void msa_translate_init(void);
 
 /* decodetree generated */
+bool decode_isa_rel6(DisasContext *ctx, uint32_t insn);
 bool decode_ase_msa(DisasContext *ctx, uint32_t insn);
 
 #endif
diff --git a/target/mips/isa-mips32r6.decode b/target/mips/isa-mips32r6.decode
new file mode 100644
index 00000000000..027585ee042
--- /dev/null
+++ b/target/mips/isa-mips32r6.decode
@@ -0,0 +1,17 @@
+# MIPS32 Release 6 instruction set
+#
+# Copyright (C) 2020  Philippe Mathieu-Daudé
+#
+# SPDX-License-Identifier: LGPL-2.1-or-later
+#
+# Reference:
+#       MIPS Architecture for Programmers Volume II-A
+#       The MIPS32 Instruction Set Reference Manual, Revision 6.06
+#       (Document Number: MD00086-2B-MIPS32BIS-AFP-06.06)
+#
+
+&lsa                rd rt rs sa
+
+@lsa                ...... rs:5 rt:5 rd:5 ... sa:2 ......   &lsa
+
+LSA                 000000 ..... ..... ..... 000 .. 000101  @lsa
diff --git a/target/mips/isa-mips64r6.decode b/target/mips/isa-mips64r6.decode
new file mode 100644
index 00000000000..e812224341e
--- /dev/null
+++ b/target/mips/isa-mips64r6.decode
@@ -0,0 +1,17 @@
+# MIPS64 Release 6 instruction set
+#
+# Copyright (C) 2020  Philippe Mathieu-Daudé
+#
+# SPDX-License-Identifier: LGPL-2.1-or-later
+#
+# Reference:
+#       MIPS Architecture for Programmers Volume II-A
+#       The MIPS64 Instruction Set Reference Manual, Revision 6.06
+#       (Document Number: MD00087-2B-MIPS64BIS-AFP-6.06)
+#
+
+&lsa                rd rt rs sa !extern
+
+@lsa                ...... rs:5 rt:5 rd:5 ... sa:2 ......   &lsa
+
+DLSA                000000 ..... ..... ..... 000 .. 010101  @lsa
diff --git a/target/mips/isa-mips_rel6_translate.c b/target/mips/isa-mips_rel6_translate.c
new file mode 100644
index 00000000000..d5872bbf8fc
--- /dev/null
+++ b/target/mips/isa-mips_rel6_translate.c
@@ -0,0 +1,37 @@
+/*
+ *  MIPS emulation for QEMU - # Release 6 translation routines
+ *
+ *  Copyright (c) 2004-2005 Jocelyn Mayer
+ *  Copyright (c) 2006 Marius Groeger (FPU operations)
+ *  Copyright (c) 2006 Thiemo Seufer (MIPS32R2 support)
+ *  Copyright (c) 2020 Philippe Mathieu-Daudé
+ *
+ * This code is licensed under the GNU GPLv2 and later.
+ */
+
+#include "qemu/osdep.h"
+#include "tcg/tcg-op.h"
+#include "exec/helper-gen.h"
+#include "translate.h"
+
+/* Include the auto-generated decoder.  */
+#include "decode-isa-mips32r6.c.inc"
+#include "decode-isa-mips64r6.c.inc"
+
+static bool trans_LSA(DisasContext *ctx, arg_LSA *a)
+{
+    return gen_LSA(ctx, a->rd, a->rt, a->rs, a->sa);
+}
+
+static bool trans_DLSA(DisasContext *ctx, arg_LSA *a)
+{
+    return gen_DLSA(ctx, a->rd, a->rt, a->rs, a->sa);
+}
+
+bool decode_isa_rel6(DisasContext *ctx, uint32_t insn)
+{
+    if (TARGET_LONG_BITS == 64 && decode_mips64r6(ctx, insn)) {
+        return true;
+    }
+    return decode_mips32r6(ctx, insn);
+}
diff --git a/target/mips/translate.c b/target/mips/translate.c
index e0439ba92d8..125b2aac848 100644
--- a/target/mips/translate.c
+++ b/target/mips/translate.c
@@ -29027,6 +29027,11 @@ static void decode_opc(CPUMIPSState *env, DisasContext *ctx)
         return;
     }
 
+    /* ISA */
+    if (isa_rel6_available(env) && decode_isa_rel6(ctx, ctx->opcode)) {
+        return;
+    }
+
     if (!decode_opc_legacy(env, ctx)) {
         gen_reserved_instruction(ctx);
     }
diff --git a/target/mips/meson.build b/target/mips/meson.build
index 8e2e5fa40b8..2d62288d604 100644
--- a/target/mips/meson.build
+++ b/target/mips/meson.build
@@ -1,4 +1,6 @@
 gen = [
+  decodetree.process('isa-mips32r6.decode', extra_args: [ '--static-decode=decode_mips32r6' ]),
+  decodetree.process('isa-mips64r6.decode', extra_args: [ '--static-decode=decode_mips64r6' ]),
   decodetree.process('mod-msa32.decode', extra_args: [ '--static-decode=decode_msa32' ]),
   decodetree.process('mod-msa64.decode', extra_args: [ '--static-decode=decode_msa64' ]),
 ]
@@ -12,6 +14,7 @@
 mips_ss.add(when: 'CONFIG_TCG', if_true: files(
   'dsp_helper.c',
   'fpu_helper.c',
+  'isa-mips_rel6_translate.c',
   'lmmi_helper.c',
   'op_helper.c',
   'mod-msa_helper.c',
