diff --git a/hw/s390x/s390-pci-bus.c b/hw/s390x/s390-pci-bus.c
index 816d17af99..e66a0dfbef 100644
--- a/hw/s390x/s390-pci-bus.c
+++ b/hw/s390x/s390-pci-bus.c
@@ -190,7 +190,10 @@ void s390_pci_sclp_deconfigure(SCCB *sccb)
         rc = SCLP_RC_NO_ACTION_REQUIRED;
         break;
     default:
-        if (pbdev->summary_ind) {
+        if (pbdev->interp && (pbdev->fh & FH_MASK_ENABLE)) {
+            /* Interpreted devices were using interrupt forwarding */
+            s390_pci_kvm_aif_disable(pbdev);
+        } else if (pbdev->summary_ind) {
             pci_dereg_irqs(pbdev);
         }
         if (pbdev->iommu->enabled) {
@@ -1082,6 +1085,7 @@ static void s390_pcihost_plug(HotplugHandler *hotplug_dev, DeviceState *dev,
                 } else {
                     DPRINTF("zPCI interpretation facilities missing.\n");
                     pbdev->interp = false;
+                    pbdev->forwarding_assist = false;
                 }
             }
             pbdev->iommu->dma_limit = s390_pci_start_dma_count(s, pbdev);
@@ -1090,11 +1094,13 @@ static void s390_pcihost_plug(HotplugHandler *hotplug_dev, DeviceState *dev,
             if (!pbdev->interp) {
                 /* Do vfio passthrough but intercept for I/O */
                 pbdev->fh |= FH_SHM_VFIO;
+                pbdev->forwarding_assist = false;
             }
         } else {
             pbdev->fh |= FH_SHM_EMUL;
             /* Always intercept emulated devices */
             pbdev->interp = false;
+            pbdev->forwarding_assist = false;
         }
 
         if (s390_pci_msix_init(pbdev) && !pbdev->interp) {
@@ -1244,7 +1250,10 @@ static void s390_pcihost_reset(DeviceState *dev)
     /* Process all pending unplug requests */
     QTAILQ_FOREACH_SAFE(pbdev, &s->zpci_devs, link, next) {
         if (pbdev->unplug_requested) {
-            if (pbdev->summary_ind) {
+            if (pbdev->interp && (pbdev->fh & FH_MASK_ENABLE)) {
+                /* Interpreted devices were using interrupt forwarding */
+                s390_pci_kvm_aif_disable(pbdev);
+            } else if (pbdev->summary_ind) {
                 pci_dereg_irqs(pbdev);
             }
             if (pbdev->iommu->enabled) {
@@ -1382,7 +1391,10 @@ static void s390_pci_device_reset(DeviceState *dev)
         break;
     }
 
-    if (pbdev->summary_ind) {
+    if (pbdev->interp && (pbdev->fh & FH_MASK_ENABLE)) {
+        /* Interpreted devices were using interrupt forwarding */
+        s390_pci_kvm_aif_disable(pbdev);
+    } else if (pbdev->summary_ind) {
         pci_dereg_irqs(pbdev);
     }
     if (pbdev->iommu->enabled) {
@@ -1428,6 +1440,8 @@ static Property s390_pci_device_properties[] = {
     DEFINE_PROP_S390_PCI_FID("fid", S390PCIBusDevice, fid),
     DEFINE_PROP_STRING("target", S390PCIBusDevice, target),
     DEFINE_PROP_BOOL("interpret", S390PCIBusDevice, interp, true),
+    DEFINE_PROP_BOOL("forwarding_assist", S390PCIBusDevice, forwarding_assist,
+                     true),
     DEFINE_PROP_END_OF_LIST(),
 };
 
diff --git a/hw/s390x/s390-pci-inst.c b/hw/s390x/s390-pci-inst.c
index 651ec38635..20a9bcc7af 100644
--- a/hw/s390x/s390-pci-inst.c
+++ b/hw/s390x/s390-pci-inst.c
@@ -1066,6 +1066,32 @@ static void fmb_update(void *opaque)
     timer_mod(pbdev->fmb_timer, t + pbdev->pci_group->zpci_group.mui);
 }
 
+static int mpcifc_reg_int_interp(S390PCIBusDevice *pbdev, ZpciFib *fib)
+{
+    int rc;
+
+    rc = s390_pci_kvm_aif_enable(pbdev, fib, pbdev->forwarding_assist);
+    if (rc) {
+        DPRINTF("Failed to enable interrupt forwarding\n");
+        return rc;
+    }
+
+    return 0;
+}
+
+static int mpcifc_dereg_int_interp(S390PCIBusDevice *pbdev, ZpciFib *fib)
+{
+    int rc;
+
+    rc = s390_pci_kvm_aif_disable(pbdev);
+    if (rc) {
+        DPRINTF("Failed to disable interrupt forwarding\n");
+        return rc;
+    }
+
+    return 0;
+}
+
 int mpcifc_service_call(S390CPU *cpu, uint8_t r1, uint64_t fiba, uint8_t ar,
                         uintptr_t ra)
 {
@@ -1120,7 +1146,12 @@ int mpcifc_service_call(S390CPU *cpu, uint8_t r1, uint64_t fiba, uint8_t ar,
 
     switch (oc) {
     case ZPCI_MOD_FC_REG_INT:
-        if (pbdev->summary_ind) {
+        if (pbdev->interp) {
+            if (mpcifc_reg_int_interp(pbdev, &fib)) {
+                cc = ZPCI_PCI_LS_ERR;
+                s390_set_status_code(env, r1, ZPCI_MOD_ST_SEQUENCE);
+            }
+        } else if (pbdev->summary_ind) {
             cc = ZPCI_PCI_LS_ERR;
             s390_set_status_code(env, r1, ZPCI_MOD_ST_SEQUENCE);
         } else if (reg_irqs(env, pbdev, fib)) {
@@ -1129,7 +1160,12 @@ int mpcifc_service_call(S390CPU *cpu, uint8_t r1, uint64_t fiba, uint8_t ar,
         }
         break;
     case ZPCI_MOD_FC_DEREG_INT:
-        if (!pbdev->summary_ind) {
+        if (pbdev->interp) {
+            if (mpcifc_dereg_int_interp(pbdev, &fib)) {
+                cc = ZPCI_PCI_LS_ERR;
+                s390_set_status_code(env, r1, ZPCI_MOD_ST_SEQUENCE);
+            }
+        } else if (!pbdev->summary_ind) {
             cc = ZPCI_PCI_LS_ERR;
             s390_set_status_code(env, r1, ZPCI_MOD_ST_SEQUENCE);
         } else {
diff --git a/hw/s390x/s390-pci-kvm.c b/hw/s390x/s390-pci-kvm.c
index e503aaf1ca..69b04a36ea 100644
--- a/hw/s390x/s390-pci-kvm.c
+++ b/hw/s390x/s390-pci-kvm.c
@@ -11,9 +11,13 @@
 
 #include "qemu/osdep.h"
 
+#include <linux/kvm.h>
+
 #include "kvm/kvm_s390x.h"
 #include "hw/s390x/pv.h"
+#include "hw/s390x/s390-pci-bus.h"
 #include "hw/s390x/s390-pci-kvm.h"
+#include "hw/s390x/s390-pci-inst.h"
 #include "cpu_models.h"
 
 bool s390_pci_kvm_interp_allowed(void)
@@ -21,3 +25,29 @@ bool s390_pci_kvm_interp_allowed(void)
     return (s390_has_feat(S390_FEAT_ZPCI_INTERP) && kvm_s390_get_zpci_op() &&
             !s390_is_pv());
 }
+
+int s390_pci_kvm_aif_enable(S390PCIBusDevice *pbdev, ZpciFib *fib, bool assist)
+{
+    struct kvm_s390_zpci_op args = {
+        .fh = pbdev->fh,
+        .op = KVM_S390_ZPCIOP_REG_AEN,
+        .u.reg_aen.ibv = fib->aibv,
+        .u.reg_aen.sb = fib->aisb,
+        .u.reg_aen.noi = FIB_DATA_NOI(fib->data),
+        .u.reg_aen.isc = FIB_DATA_ISC(fib->data),
+        .u.reg_aen.sbo = FIB_DATA_AISBO(fib->data),
+        .u.reg_aen.flags = (assist) ? 0 : KVM_S390_ZPCIOP_REGAEN_HOST
+    };
+
+    return kvm_vm_ioctl(kvm_state, KVM_S390_ZPCI_OP, &args);
+}
+
+int s390_pci_kvm_aif_disable(S390PCIBusDevice *pbdev)
+{
+    struct kvm_s390_zpci_op args = {
+        .fh = pbdev->fh,
+        .op = KVM_S390_ZPCIOP_DEREG_AEN
+    };
+
+    return kvm_vm_ioctl(kvm_state, KVM_S390_ZPCI_OP, &args);
+}
diff --git a/include/hw/s390x/s390-pci-bus.h b/include/hw/s390x/s390-pci-bus.h
index a9843dfe97..5b09f0cf2f 100644
--- a/include/hw/s390x/s390-pci-bus.h
+++ b/include/hw/s390x/s390-pci-bus.h
@@ -351,6 +351,7 @@ struct S390PCIBusDevice {
     bool pci_unplug_request_processed;
     bool unplug_requested;
     bool interp;
+    bool forwarding_assist;
     QTAILQ_ENTRY(S390PCIBusDevice) link;
 };
 
diff --git a/include/hw/s390x/s390-pci-kvm.h b/include/hw/s390x/s390-pci-kvm.h
index 80a2e7d0ca..933814a402 100644
--- a/include/hw/s390x/s390-pci-kvm.h
+++ b/include/hw/s390x/s390-pci-kvm.h
@@ -12,13 +12,27 @@
 #ifndef HW_S390_PCI_KVM_H
 #define HW_S390_PCI_KVM_H
 
+#include "hw/s390x/s390-pci-bus.h"
+#include "hw/s390x/s390-pci-inst.h"
+
 #ifdef CONFIG_KVM
 bool s390_pci_kvm_interp_allowed(void);
+int s390_pci_kvm_aif_enable(S390PCIBusDevice *pbdev, ZpciFib *fib, bool assist);
+int s390_pci_kvm_aif_disable(S390PCIBusDevice *pbdev);
 #else
 static inline bool s390_pci_kvm_interp_allowed(void)
 {
     return false;
 }
+static inline int s390_pci_kvm_aif_enable(S390PCIBusDevice *pbdev, ZpciFib *fib,
+                                          bool assist)
+{
+    return -EINVAL;
+}
+static inline int s390_pci_kvm_aif_disable(S390PCIBusDevice *pbdev)
+{
+    return -EINVAL;
+}
 #endif
 
 #endif
