diff --git a/target/s390x/helper.h b/target/s390x/helper.h
index fb50b404db04..1f9f0b463bdb 100644
--- a/target/s390x/helper.h
+++ b/target/s390x/helper.h
@@ -230,6 +230,12 @@ DEF_HELPER_FLAGS_4(gvec_vfene32, TCG_CALL_NO_RWG, void, ptr, cptr, cptr, i32)
 DEF_HELPER_5(gvec_vfene_cc8, void, ptr, cptr, cptr, env, i32)
 DEF_HELPER_5(gvec_vfene_cc16, void, ptr, cptr, cptr, env, i32)
 DEF_HELPER_5(gvec_vfene_cc32, void, ptr, cptr, cptr, env, i32)
+DEF_HELPER_FLAGS_3(gvec_vistr8, TCG_CALL_NO_RWG, void, ptr, cptr, i32)
+DEF_HELPER_FLAGS_3(gvec_vistr16, TCG_CALL_NO_RWG, void, ptr, cptr, i32)
+DEF_HELPER_FLAGS_3(gvec_vistr32, TCG_CALL_NO_RWG, void, ptr, cptr, i32)
+DEF_HELPER_4(gvec_vistr_cc8, void, ptr, cptr, env, i32)
+DEF_HELPER_4(gvec_vistr_cc16, void, ptr, cptr, env, i32)
+DEF_HELPER_4(gvec_vistr_cc32, void, ptr, cptr, env, i32)
 
 #ifndef CONFIG_USER_ONLY
 DEF_HELPER_3(servc, i32, env, i64, i64)
diff --git a/target/s390x/insn-data.def b/target/s390x/insn-data.def
index d03c1ee0b3ab..b4a6b5960864 100644
--- a/target/s390x/insn-data.def
+++ b/target/s390x/insn-data.def
@@ -1199,6 +1199,8 @@
     F(0xe780, VFEE,    VRR_b, V,   0, 0, 0, 0, vfee, 0, IF_VEC)
 /* VECTOR FIND ELEMENT NOT EQUAL */
     F(0xe781, VFENE,   VRR_b, V,   0, 0, 0, 0, vfene, 0, IF_VEC)
+/* VECTOR ISOLATE STRING */
+    F(0xe75c, VISTR,   VRR_a, V,   0, 0, 0, 0, vistr, 0, IF_VEC)
 
 #ifndef CONFIG_USER_ONLY
 /* COMPARE AND SWAP AND PURGE */
diff --git a/target/s390x/translate_vx.inc.c b/target/s390x/translate_vx.inc.c
index 1ad0b6251721..08a62eab5263 100644
--- a/target/s390x/translate_vx.inc.c
+++ b/target/s390x/translate_vx.inc.c
@@ -188,6 +188,9 @@ static void get_vec_element_ptr_i64(TCGv_ptr ptr, uint8_t reg, TCGv_i64 enr,
 #define gen_gvec_2s(v1, v2, c, gen) \
     tcg_gen_gvec_2s(vec_full_reg_offset(v1), vec_full_reg_offset(v2), \
                     16, 16, c, gen)
+#define gen_gvec_2_ool(v1, v2, data, fn) \
+    tcg_gen_gvec_2_ool(vec_full_reg_offset(v1), vec_full_reg_offset(v2), \
+                       16, 16, data, fn)
 #define gen_gvec_2i_ool(v1, v2, c, data, fn) \
     tcg_gen_gvec_2i_ool(vec_full_reg_offset(v1), vec_full_reg_offset(v2), \
                         c, 16, 16, data, fn)
@@ -2445,3 +2448,34 @@ static DisasJumpType op_vfene(DisasContext *s, DisasOps *o)
     }
     return DISAS_NEXT;
 }
+
+static DisasJumpType op_vistr(DisasContext *s, DisasOps *o)
+{
+    const uint8_t es = get_field(s->fields, m4);
+    const uint8_t m5 = get_field(s->fields, m5);
+    static gen_helper_gvec_2 * const g[3] = {
+        gen_helper_gvec_vistr8,
+        gen_helper_gvec_vistr16,
+        gen_helper_gvec_vistr32,
+    };
+    static gen_helper_gvec_2_ptr * const g_cc[3] = {
+        gen_helper_gvec_vistr_cc8,
+        gen_helper_gvec_vistr_cc16,
+        gen_helper_gvec_vistr_cc32,
+    };
+
+    if (es > ES_32 || m5 & ~0x1) {
+        gen_program_exception(s, PGM_SPECIFICATION);
+        return DISAS_NORETURN;
+    }
+
+    if (extract32(m5, 0, 1)) {
+        gen_gvec_2_ptr(get_field(s->fields, v1), get_field(s->fields, v2),
+                       cpu_env, 0, g_cc[es]);
+        set_cc_static(s);
+    } else {
+        gen_gvec_2_ool(get_field(s->fields, v1), get_field(s->fields, v2), 0,
+                       g[es]);
+    }
+    return DISAS_NEXT;
+}
diff --git a/target/s390x/vec_string_helper.c b/target/s390x/vec_string_helper.c
index 0ee3470112b5..6bafa23bd723 100644
--- a/target/s390x/vec_string_helper.c
+++ b/target/s390x/vec_string_helper.c
@@ -283,3 +283,48 @@ void HELPER(gvec_vfene_cc##BITS)(void *v1, const void *v2, const void *v3,     \
 DEF_VFENE_CC_HELPER(8)
 DEF_VFENE_CC_HELPER(16)
 DEF_VFENE_CC_HELPER(32)
+
+static int vistr(void *v1, const void *v2, uint8_t es)
+{
+    const uint64_t mask = get_element_lsbs_mask(es);
+    uint64_t a0 = s390_vec_read_element64(v2, 0);
+    uint64_t a1 = s390_vec_read_element64(v2, 1);
+    uint64_t z;
+    int cc = 3;
+
+    z = zero_search(a0, mask);
+    if (z) {
+        a0 &= ~(-1ull >> clz64(z));
+        a1 = 0;
+        cc = 0;
+    } else {
+        z = zero_search(a1, mask);
+        if (z) {
+            a1 &= ~(-1ull >> clz64(z));
+            cc = 0;
+        }
+    }
+
+    s390_vec_write_element64(v1, 0, a0);
+    s390_vec_write_element64(v1, 1, a1);
+    return cc;
+}
+
+#define DEF_VISTR_HELPER(BITS)                                                 \
+void HELPER(gvec_vistr##BITS)(void *v1, const void *v2, uint32_t desc)         \
+{                                                                              \
+    vistr(v1, v2, MO_##BITS);                                                  \
+}
+DEF_VISTR_HELPER(8)
+DEF_VISTR_HELPER(16)
+DEF_VISTR_HELPER(32)
+
+#define DEF_VISTR_CC_HELPER(BITS)                                              \
+void HELPER(gvec_vistr_cc##BITS)(void *v1, const void *v2, CPUS390XState *env, \
+                                uint32_t desc)                                 \
+{                                                                              \
+    env->cc_op = vistr(v1, v2, MO_##BITS);                                     \
+}
+DEF_VISTR_CC_HELPER(8)
+DEF_VISTR_CC_HELPER(16)
+DEF_VISTR_CC_HELPER(32)
